PepFlow: Direct Conformational Sampling From Peptide Energy Landscapes
Explore PepFlow, a deep learning approach for direct conformational sampling of peptides. Learn about its modular design, hypernetwork integration, and applications in drug discovery.
Binding Affinity Prediction with ML-Based Docking - Lab 2
Explore ML-based docking for binding affinity prediction in drug discovery, featuring insights from experts Stephan Thaler and Cristian Gabellini.
Protein Folding and Design - Day 5
Explore protein folding and design techniques with Alex Tong, delving into advanced machine learning applications for drug discovery and structural biology.
Coarse Grained Biological Systems - Day 2
Explore coarse-grained biological systems in drug discovery with Jacopo Venturin, delving into advanced machine learning applications for pharmaceutical research.
OpenFold: Lessons Learned and Insights from Rebuilding and Retraining AlphaFold2
Explore insights from rebuilding AlphaFold2, including performance analysis, learning mechanisms, and current progress in protein structure prediction.
Path Integral Stochastic Optimal Control for Sampling Transition Paths in Molecular Dynamics
Explore stochastic optimal control for sampling molecular transition paths, considering full geometry without relying on collective variables. Applicable to larger proteins like Polyproline and Chignolin.
Direct cDNA Synthesis Using Template Switching RT for Highly Sensitive Gene Expression Analysis
Explore reverse transcriptases, template switching RT, and direct cDNA synthesis from cell lysates for enhanced single-cell analysis and gene expression studies.
Steroid and Bile Acid Metabolism by the Gut Bacterium, Clostridium scindens
Explore gut microbiology and steroid metabolism with Dr. Ridlon, focusing on Clostridium scindens' role in gastrointestinal diseases and potential treatment strategies.
Functional Amyloid Confer Defense Against Predatory Bacteria
Explore how functional amyloid proteins defend against predatory bacteria, focusing on B. bacteriovorus and its infectious life cycle in Gram-negative bacteria.
Impact of Cell Background on Small Compound Target Deconvolution by CETSA Coupled to Mass Spectrometry
Explore CETSA's role in target engagement and mode of action deconvolution, focusing on cell background impact and mass spectrometry coupling for small compound analysis.
Lessons Learned by Studying a Mucin-Dependent MAPK Pathway in a Model Fungal System
Explore signal transduction pathways, focusing on MAPK pathways in fungi. Gain insights into signal specificity, shared components, and implications for disease research.
Protein Folding Algorithms - Lecture 9
Explore protein folding algorithms, their applications, and computational approaches in structural biology and drug discovery.
Benchmark and Critical Evaluation for ML Force Fields with Molecular Simulations
Explore benchmarking and critical evaluation of machine learning force fields in molecular simulations, focusing on realistic MD trajectories beyond force prediction accuracy.
The Evolution of Carbon Fixation: Studying Form I Rubisco Using Ancestral Sequence Reconstruction and Mass Photometry
Explore the evolutionary trajectory of Form I Rubisco, the key CO2-fixing enzyme, using ancestral sequence reconstruction and mass photometry to unravel its complex development.
Cracking the Nuclear Codes: Finding Order in Chaos
Explore interdisciplinary research blending virology, biology, and genomics to uncover genetic circuits in viral replication and cancer growth, with insights from the Salk Institute.
Kinetic Proofreading in Transcriptional Regulation - Daniel R. Larson
Explore kinetic proofreading in transcriptional regulation, examining its role in gene expression control and chromatin organization dynamics.
Chromatin 'Readers' as Molecular Architects in Shaping Metabolic Landscape
Explore chromatin 'readers' as molecular architects shaping metabolic landscapes, delving into interdisciplinary aspects of chromatin organization and gene regulation.
ATP-Dependent Remodeling of Hexasomes, Nucleosomes and Chromatin Condensates
Explore ATP-dependent chromatin remodeling, focusing on INO80's unique hexasome preference and its impact on higher-order chromatin organization. Gain insights into novel mechanisms regulating genome accessibility.
High-yield Vesicle Packaged Recombinant Protein Production from E. Coli
Explore high-yield vesicle packaged recombinant protein production from E. coli with Dr. Dan Mulvihill. Gain insights into microbial cell biology and innovative bacterial technologies for biotechnology applications.
Purification of Proteins and Peptides Using Self-removing Tags
Explore self-removing tags for protein and peptide purification, focusing on intein-based technologies, their applications, and optimization strategies for effective recombinant protein production.
Accelerate Discovery and Development by Optimizing the Protein Engineering Workflow
Optimize protein engineering workflow for enhanced biologics development. Learn advanced gene synthesis and expression techniques to boost yields and accelerate discovery in mammalian systems.