Explore nonalcoholic fatty liver disease in this comprehensive lecture from the 9th Annual UCLA-Mellinkoff Gastroenterology and Hepatology Symposium. Delve into a case presentation, family history analysis, and laboratory data interpretation. Examine disease severity, nomenclature changes, and the spectrum of conditions from simple steatosis to more advanced stages. Learn about global prevalence, noninvasive testing methods including elastography, and how to interpret indeterminate results. Discover treatment approaches, including lifestyle modifications, weight loss strategies, bariatric surgery options, and pharmacotherapy. Understand the use of Vitamin E, its dosage, and FDA approval status. Review ongoing clinical trials and gain valuable insights into managing this increasingly common liver condition.