Explore quantitative models of genetic variation in cis-regulation through this informative conference talk by Pejman Mohammadi at the 2022 Computational Genomics Summer Institute (CGSI). Delve into the complexities of haplotype-aware modeling of cis-regulatory effects and understand the current gaps in eQTL data. Learn about the quantification of regulatory effect sizes of cis-acting genetic variation using allelic fold change. Gain insights from the GTEx Consortium atlas of genetic regulatory effects across human tissues. This 52-minute presentation offers a comprehensive overview of recent advancements in the field, referencing key papers and research findings to provide a thorough understanding of the subject matter.