Dive into the behind-the-scenes process of creating gnomAD v4 in this 40-minute Medical and Population Genetics Primer talk from the Broad Institute. Explore the fundamentals of gnomAD, its creation process, data processing techniques, and quality control measures. Learn about variant quality assessment, the release process, and concepts of intolerance and constraint. Gain insights into frequently asked questions and participate in a Q&A session. This informative presentation, delivered by Katherine Chao, offers a comprehensive overview of the latest developments in genomic data analysis, suitable for research technicians, graduate students, postdoctoral fellows, and established investigators entering the field of complex trait genetics.