Explore the complexities of adaptation to changing environments in this comprehensive lecture by Luis-Miguel Chevin from the International Centre for Theoretical Sciences. Delve into the theoretical and empirical approaches used to understand polygenic adaptation as part of a broader program on phenotypic variation and genetic architecture. Learn about the integration of different views on adaptive dynamics, from large changes at few genetic loci to infinitesimal changes across many. Gain insights into quantitative evolutionary biology, with a focus on polygenic traits influencing various aspects of life, from crop yields to human height and complex diseases. Discover how this lecture contributes to the program's goal of developing a unified framework for describing and relating different adaptation scenarios to empirical data.