Explore stochasticity in transcription through this 50-minute Medical and Population Genetics Primer lecture from the Broad Institute. Delve into single-cell data analysis of immune cell types in autoimmunity, modeling dynamic regulatory elements, and identifying cell-state-dependent peaks using continuous Poisson GLM frameworks. Examine peak accessibility profiles, genome annotation based on peak sets, and the identification of peak-gene-cell state trios associated with autoimmune diseases. Investigate transcriptional bursting and how transcriptional heterogeneity propagates from transcription factors to target genes. Gain insights into cutting-edge genetics research and its applications in understanding complex traits and diseases.