Explore the intricate mechanism of KATP channels in this 28-minute conference talk presented by Tim Cardozo M.D. Ph.D. from NYU at MolSoft's UGM 2023. Delve into the sub-classes of Kir channels and unravel the mystery of how Palm opens the channel. Examine the channel structure and mechanism, focusing on gates, and discover a mechanistic hypothesis derived from modeling, specifically the Palmitoyl-C166. Learn about the test of this hypothesis and the phenotypic validation of CL705G. Gain insights into future directions in this field of research, providing a comprehensive overview of chemical probing techniques applied to KATP channel mechanisms.