Explore recent advancements in petabase-scale genomics through this informative conference talk by Rayan Chikhi at the Computational Genomics Summer Institute (CGSI) 2022. Delve into cutting-edge research from Institut Pasteur & CNRS, focusing on whole-genome assembly of long reads and viral discovery using large-scale sequence alignment. Learn about minimizer-space de Bruijn graphs, which enable genome assembly in minutes on personal computers, and discover the potential of petabase-scale sequence alignment for identifying novel viruses. Gain insights into efficient construction of Bloom filters for large sequencing data collections using kmtricks. Understand the implications of these technological breakthroughs for the future of genomics research and their potential applications in various fields of study.