Explore the fundamentals of motif discovery and transcription factor binding site analysis in this comprehensive 52-minute video tutorial. Delve into the basics of motifs, transcription factors, and regulatory regions, including promoters, enhancers, silencers, and insulators. Learn how motifs are represented and discover the questions that Transcription Factor Binding Site (TFBS) analysis can answer. Gain insights into various tools for motif discovery and explore motif databases. Follow along with a practical demonstration using Homer to find enriched de novo and canonical motifs in regions quantified by ChIP sequencing. Discover methods for identifying instances of motifs of interest in peaks. Enhance your understanding of gene regulation and epigenomics through this collaborative presentation with geneXplain GmbH, a renowned provider of bioinformatics, systems biology, and cheminformatics resources.