Assymetric divergence following ancient vertebrate WGDs
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A challenge... distinguishing between evolutionary scenarios
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The OU-model: A framework to model expression evolution
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The experiment
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Tests for expression level shift
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Tissue specific evolution?
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Signatures of ongoing pseudogenization ?
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Are particular cellular functions
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Brief summary 2: expression evolution following WGD
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Approach: ATAC-seq&TFBS footprinting
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Sanity check = OK
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Cis-regulatory evolution and tissue specificity
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Does Tes contribute to novel 'adaptive' expression phenotypes?
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Brief summary 3: CREs and duplicate expression evolution
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Some concluding thoughts
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Acknowledgements
Description:
Explore the evolution of gene regulation following whole genome duplication in salmonids through this comprehensive seminar. Delve into the fascinating world of salmonid genomics, focusing on the Atlantic salmon as a model for genome evolution after whole genome duplication. Examine gene loss and retention patterns, tissue regulatory divergence, and the challenges of distinguishing between evolutionary scenarios. Learn about the Ornstein-Uhlenbeck model as a framework for modeling expression evolution. Investigate expression level shifts, tissue-specific evolution, and ongoing pseudogenization. Discover the role of cis-regulatory elements in duplicate expression evolution through ATAC-seq and TFBS footprinting techniques. Gain insights into how transposable elements contribute to novel adaptive expression phenotypes in salmonids. Conclude with a summary of key findings and their implications for understanding genome evolution in these economically and culturally significant fish species.
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Evolution of Gene Regulation Following Whole Genome Duplication in Salmonids