Mass spectrometry to identify the building blocks within complexes
17
Micelles protect membrane complexes and lipid binding remains intact
18
From micelles to membrane proteins in the gas phase
19
ATP Synthase - 95:1 DDM: protein
20
Mass spectrum of intact ATPase from Thermus thermophilus
21
Mass spectral assignment strategy - Massign
22
New ways to study how small molecules stabilise membrane proteins
23
Monitoring unfolding of AqpZ as a function of POPG binding
24
P-glycoprotein - an ABC transporter and drug efflux pump
25
Looking for a small difference
26
Mechanisms of drug resistance
27
Zinc binding to a human metalloprotease ZMPSTE24
28
Progeria is a common side effect of anti- HIV drugs
29
Processing of lamin A peptides is inhibited by drug binding
30
Sugar transporter semiSWEET - remodeling the lipid bilayer
31
From Neon to rotary motors to flipping lipids and drugs
Description:
Explore a groundbreaking lecture on structural biology that revolutionized the field by studying proteins in the vapor phase. Delve into Carol Robinson's innovative research, which provides a new perspective on protein interactions and their behavior beyond solid and solution phases. Learn how this unconventional approach has proven invaluable in understanding dynamic interactions between proteins, lipids, and drugs. Discover the journey from early mass spectrometry techniques to cutting-edge applications in studying membrane proteins, drug resistance mechanisms, and the impact on human health. Gain insights into the scientific goals, methodologies, and breakthroughs that have shaped this new phase of structural biology, including the analysis of complex protein structures, evolutionary assembly pathways, and the role of lipids in protein stability.
A New Phase for Structural Biology - With Carol Robinson