Explore a comprehensive lecture by Stanford University Professor William Greenleaf that delves into how the human genome's physical structure influences cellular diversity. Learn about cutting-edge research cataloging regulatory elements and transcription factor patterns active in human fetal development, while examining single molecule approaches that quantitatively analyze relationships between transcription factor binding sites, occupancy, and gene expression in human cells. Discover how this interdisciplinary research combines molecular biology, computer science, bioengineering, and genomics to understand the physical "regulome" - the controlling factors in genetic information interpretation. Gain insights from Greenleaf's extensive background in physics, computer science, and molecular biology, and his pioneering work developing new fluorescence-based high-throughput sequencing methodologies to understand genomic and epigenomic regulation in both health and disease states.