Explore the high incidence of coronary artery disease (CAD) among South Asians in this informative lecture. Delve into the primary mechanisms underlying the increased risk, comparing statistics for South Asians living abroad and in their home countries. Learn about Stanford's South Asian Translational Heart Initiative (SSATHI), a dedicated clinic and research program aimed at reducing CAD burden in this population. Discover key risk factors, including family history, insulin resistance, obesity, and the "thin fat syndrome." Understand the importance of waist circumference measurements and nontraditional risk factors. Gain insights into SSATHI's clinical and research missions, imaging components, and personalized medicine approach. Conclude with practical advice on what individuals can do to mitigate their risk, including the significance of HDL to triglycerides ratio.