Explore the complex relationship between fatigue and frailty in the oldest-old population through this 48-minute grand rounds presentation by Dr. Peter Martin from Iowa State University. Delve into demographic changes, profiles of aging, and the global centenarian population while examining the concept of frailty and its impact on quality of life. Investigate the various components of fatigue, including its connections to depression and nutrition. Learn about the Healthiest Aims and Homebeast Exercise studies, their participants, and key findings related to life satisfaction and cognitive function. Gain valuable insights into the challenges faced by the oldest-old adults and potential interventions to improve their well-being.