#G Protein Coupled Receptors

Explore G protein-coupled receptors and receptor activity-modifying proteins interactions through multiplexed mapping, uncovering potential therapeutic targets for various human diseases.

Nobel laureate Dr. Lefkowitz shares his journey from reluctant scientist to groundbreaking researcher, exploring pivotal moments and lessons learned that led to his revolutionary work on G-protein coupled receptors.

Explore SPR microscopy's role in drug discovery, focusing on label-free, real-time measurements of small molecule binding to GPCRs. Learn about pH-dependent studies and limitations of GPR4 antagonists.

Explore spatial mapping of pain-related GPCRs and biomarkers in mouse brain using advanced RNAscope HiPlex v2 and RNA-protein co-detection techniques for single-cell resolution gene expression analysis.

Explore the cAMP pathway and its role as a second messenger in cellular signaling, understanding its mechanisms and biological significance.