Explore the latest developments in managing localized renal tumors in this comprehensive Yale Interventional Radiology Grand Rounds lecture. Delve into the changing patterns of detection and presentation, hereditary risk factors, genetic testing evolution, and proper workup procedures for renal masses. Learn about tumor complexity assessment, ancillary studies, and renal functional evaluation. Examine the role of renal mass biopsy, morphologic vs. genomic classification, and the future of localized disease management. Discover the expanding role of interventional oncologists and the importance of a multi-disciplinary approach in treating renal tumors. Gain valuable insights from Dr. Brian M. Shuch, Assistant Professor of Urology and Radiology and Biomedical Imaging at Yale University School of Medicine, as he shares key take-home messages for improved patient care.