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1
Start
2
Introduction
3
Preface
4
Mathematical Theory and Scientific Understanding
5
Population Genetics and Evolutionary Hypotheses
6
Random Genetic Drift at a Neutral Locus is Inversely Proportional to the Effective Population Size
7
Buri's Big Drift Experiment
8
Most Demographic Deviations From the Standard Model Cause Ne to be the Census Number
9
Genetic Hitch-hiking Via Selective Sweeps Depresses Ne Below the Actual Census Size
10
Allele-Frequency Trajectories for Mutations in Replicate Experimental Yeast Populations
11
Selection Against the Constant Background Rain of Deleterious Mutations Further Depresses N.
12
The Concept of Effective Neutrality
13
Probability of Fixation of a New Mutation
14
Negative Scaling of N with Organism Size Defines the Range of Mutations Discernible by Selection
15
The Drift-Barrier Hypothesis
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Drift Barriers in Biology
17
Evolution of Mutation Rates
18
Quasi-Equilibrium Mutation Rates Resulting From Deleterious-Mutation Load
19
Analysis of Genome Stability with a Mutation-accumulation Experiment
20
Mutation in Small vs. Large Genomes
21
Mutation-accumulation Studies Across the Tree of Life
22
Drake's 1991 Law for Mutation-Rate Evolution Revisited
23
Evaluation of the Drift-Barrier Hypothesis
24
Inverse Scaling Between the Genome-wide Deleterious Mutation Rate and the Effective Population Size
25
The Three Molecular Lines of Defense Against Mutation
26
Polymerase Error Rates Are Magnified in Enzymes Involved in Fewer Nucleotide Transactions
27
Evolution of Recombination Rates
28
Inverse Scaling of the Recombination Rate / Physical Distance and Genome Size is a Natural Outcome of "One Crossover / Chromosome Arm" Rule
29
Relative Magnitudes of Recombination c and Mutation u Rates Per Nucleotide Site
30
Reduced Levels of Variation in Regions of Low Recombination
31
Summary
32
Q&A
33
Thank You
Description:
Explore the fundamental concepts of population genetics and evolutionary biology in this comprehensive lecture from the Fifth Bangalore School on Population Genetics and Evolution. Delve into topics such as random genetic drift, effective population size, mutation rates, and recombination rates. Examine key experiments and studies that have shaped our understanding of evolutionary processes. Learn about the drift-barrier hypothesis and its implications for genome stability and mutation accumulation across different organisms. Gain insights into the mathematical theories and models used to predict and test evolutionary changes in populations. Discover how population genetics provides a crucial framework for integrating various biological disciplines and understanding the mechanisms driving evolution.

The Population-Genetic Environment - Lecture 1

International Centre for Theoretical Sciences
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#Science #Biology #Genetics #Population Genetics #Evolutionary Biology #Molecular Evolution #Evolution #Natural Selection #Genetic Drift
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