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The logistics of shaping a vertebrate embryo in developmental space and time
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Everything complex is simple to begin with..
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The "teenage angst" of embryos
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Early zebrafish embryos as an experimental paradigm to understand cell size scaling during embryonic development
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Cells decrease in size during early zebrafish development
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Cell size decrease during early zebrafish development
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Dynamically evolving cell sizes are distributed in conserved proportions during early development
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Why study cell size during early embryonic development?
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How does one change cell size when one does not know what regulates cell size?
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Generation of zebrafish haploids and tetraploids
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Cell sizes in haploid and tetraploid zebrafish embryos are altered in comparison to diploid embryos
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Haploid and tetraploid embryos generate cell collectives of altered sizes
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Movement is an inherently complex phenomenon
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Gastrulation is the phenomenon of en mass cell migration in animal embryos,
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Model organisms allow us to study evolutionary commonalities between species
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The conundrum
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Early cell divisions in embryos result in constantly shrinking cell sizes to generate a cell mass
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Generated zebrafish haploids and tetraploids to create embryos made of altered cell sizes
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Haploid and tetraploid embryos are delayed in epiboly initiation, progression and gastrulate abnormally
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Haploids and tetraploids embryos have defects in anterior migration,
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Haploid and tetraploid embryos generate cell collectives of altered sizes
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Dynamically evolving cell sizes are distributed in conserved proportions during early development
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Movement in an embryological context always gives rise to form
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Haploids and tetraploids embryos have defects in anterior migration,
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If cells in diploid embryos are made to be of suboptimal sizes,
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If smaller cells are induced to achieve normal cell size optima,
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Do sub-optimally sized cells migrate aberrantly during gastrulation?
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Do sub-optimally sized cells migrate aberrantly during gastrulation? - Yes
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The migratory behaviour of cells in a suboptimal sized cell collective is altered
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Do sub-optimally sized cells migrate aberrantly during gastrulation? Analysing cells in an embryo by generating mosaic embryos
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Smaller or larger cells continue to migrate aberrantly during gastrulation,
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Migration is influenced by environment of the cell collective
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Why does a cell of suboptimal size migrate poorly? Assaying membrane action dynamics during gastrulation in live embryos
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Membrane protrusion dynamics change when cell size changes
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Membrane protrusion dynamics of action containing protrusions change when cell size changes
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Quick recap...
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Why is this interesting, besides it just being interesting?
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Endodermal organogenesis and function is also compromised
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The big question: How do embryos set up cell size optima?
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The logistics of shaping a vertebrate embryo in developmental space and time
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Vertebrate Embryogenesis Group
Description:
Explore the intricate process of vertebrate embryo development in this 91-minute lecture from the International Centre for Theoretical Sciences' discussion meeting on theoretical biology. Delve into the complexities of cell size regulation and its impact on embryonic development using zebrafish as a model organism. Examine how cell size affects migration during gastrulation, and investigate the consequences of altered cell sizes in haploid and tetraploid embryos. Learn about experimental techniques for manipulating cell size and observe the effects on membrane dynamics and organ formation. Gain insights into the fundamental question of how embryos establish optimal cell sizes and the broader implications for understanding vertebrate embryogenesis.

The Logistics of Shaping a Vertebrate Embryo in Developmental Space and Time by Sreelaja Nair

International Centre for Theoretical Sciences
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#Science #Biology #Developmental Biology #Embryonic Development #Cell Biology #Cell Migration #Theoretical Biology
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The logistics of shaping a vertebrate embryo in developmental space and time