Explore the intricacies of Protocol Buffers (Protobuf) in this comprehensive 28-minute talk from PyCon US. Dive into serialization concepts, comparing static vs. dynamic typing and textual vs. binary formats. Learn about popular serialization frameworks and discover why Protobuf stands out. Gain insights into Protobuf's performance challenges, async synchronization, field encoding, and data deduplication. Understand the pros and cons of gRPC and explore Protobuf implementation over websocket or HTTP. Master effective Protobuf usage, from basic concepts to advanced optimization techniques, to enhance your software engineering skills.