Explore a comprehensive medical lecture on Systemic Lupus Erythematosus (SLE), covering its etiology, pathophysiology, clinical presentation, diagnosis, and treatment. Delve into the new EULAR/ACR 2022 criteria for SLE classification, learn about neonatal lupus, and understand the importance of ASCVD risk assessment. Gain insights into SLE symptoms through a helpful mnemonic, and discover the latest diagnostic tests and management strategies. Conclude with a summary of key points and monitoring techniques for this complex autoimmune disorder, essential for USMLE preparation and medical professionals.