Explore how NASA leverages an on-premise OpenStack cloud infrastructure to support critical space science missions in this 43-minute technical presentation. Discover the architectural details behind supporting projects like ICESAT-2 and the Nancy Grace Roman Space Telescope, while learning about the implementation of software-defined infrastructure that enables rapid response to diverse scientific team requirements. NASA experts Jonathan Mills and Robert Budden delve into their cloud architecture's strengths and challenges, covering essential components like compute flavors, networking, storage, and GPU integration. Gain insights into real-world applications of OpenStack in space research, including BGP implementation, neutron networks, and HPC center deployment strategies. The presentation, organized in collaboration with the OpenStack Scientific SIG, concludes with an interactive Q&A session addressing practical implementation concerns.