Explore a comprehensive conference talk on promoting healthy development for children and youth in low- and middle-income countries. Delve into opportunities, strategies, and challenges faced in these regions, while examining initiatives and evidence-based approaches. Learn about multimedia strategies, partnerships, and the concept of "leapfrogging" in developmental science. Discover the importance of capacity building, sensitivity, and continuous quality improvement in creating effective interventions. Gain insights from three outstanding researchers as they discuss macro-level shocks, reverse engineering, and the urgency of evidence-based practices. Understand the guiding principles for effective programs, including multiple data sources and regular feedback, as well as the efficacy-efficiency-scalability cycle. Engage with this thought-provoking presentation that aims to advance global developmental science and improve outcomes for children and youth in resource-limited settings.