Explore a conference talk from Derbycon 2015 that delves into Moving Target Defense (MTD) and its applications in cybersecurity. Learn about the concept of MTD, its comparison to Star Trek's shield nutation, and various MTD techniques such as instruction-set randomization and software diversity. Examine the evolution of botnets, from early centralized models to sophisticated decentralized networks, and understand the lessons learned from this progression. Investigate the relationship between cloud computing and botnets, and discover how MTD principles can be applied to protect distributed systems. Gain insights into strategies like evolving distributed system topologies, moving virtual machines in the cloud, and network-aware VM migration to enhance security against zero-day vulnerabilities and other attacks.