Explore the complexities of knowledge-seeking and explanation in this thought-provoking lecture by Simon DeDeo from the Santa Fe Institute. Delve into the tension between understanding and prediction, the diverse approaches to knowledge acquisition, and the importance of balanced epistemology in navigating societal changes. Examine how computational techniques can be applied to the history of science and information processing at a societal scale. Investigate the challenges posed by digital technologies and the COVID-19 pandemic in reshaping our understanding of the world. Gain insights into Bayesian reasoning, consilience, and the evolution of scientific theories from alchemy to electromagnetism. Consider the implications of information-processing thresholds in social evolution and the stability of complex systems. Reflect on the role of explanatory values in scientific progress and decision-making in an increasingly complex world.