Discover how to distribute Python applications without requiring a Python installation in this 27-minute conference talk from EuroPython 2024. Learn about eGenix PyRun, an open-source, compressed, single-file Python runtime that occupies only 5 MB of disk space. Explore its applications in shipping pure Python products, creating lightweight Docker images, and serving as a venv alternative for truly isolated applications across Unix platforms. Gain insights into PyRun's construction from the Python source tree, the process of creating single-file Python apps, and its practical use cases. Understand the project's roadmap, limitations, and its recent move to Github as it relaunches for the wider open-source and Python community.