Explore cutting-edge approaches to phylogenetic reconstruction in this 56-minute conference talk by Sagi Snir at the Computational Genomics Summer Institute (CGSI) 2023. Delve into innovative methods for harnessing genome dynamics, including horizontal gene transfer, gene content analysis, and whole-genome microsynteny. Learn about the random walk approach to horizontal gene transfer phylogenetics, genome-wide techniques for prokaryotic phylogeny, and the application of microsynteny-based phylogeny in angiosperms. Gain insights from related research papers that form the foundation of these advanced phylogenetic reconstruction techniques, enhancing your understanding of computational genomics and evolutionary biology.