Explore the applications of k-mers in computational genomics through this informative chalk talk by Rayan Chikhi at the Computational Genomics Summer Institute (CGSI) 2024. Delve into the world of k-mer analysis and its significance in bioinformatics. Learn about recent advancements in k-mer-based tools and data structures, including k_mdiff for large-scale differential k-mer analyses and Kmtricks for efficient construction of bloom filters in large sequencing data collections. Gain insights into the representation of k-long DNA sequences and their importance in genomic research. This 25-minute presentation offers a comprehensive overview of k-mer applications, drawing from Chikhi's recent publications and expertise in the field.