Explore powerful design patterns and best practices for building cloud-scale services using Orleans in this comprehensive conference talk. Delve into challenges faced when developing cloud applications and learn how to implement effective solutions such as state-machines, smart-caches, and event-sourcing. Discover key architectural patterns including Object Storage Grain, Registry Usage, Smart Cache implementation, Event-Sourcing Smart Cache, Aggregate Grain State, and State Machine design. Gain insights into Orleans Streaming and its application in analytics. Understand the cross-cutting benefits of Orleans and avoid common anti-patterns in cloud service development. Master the techniques used by Microsoft to create scalable services for products like Halo and Skype, and apply these strategies to your own projects.