Explore non-IgE mediated hypersensitivity drug reactions in this comprehensive physician grand rounds presentation. Delve into various types of drug reactions, their prevalence, and specific syndromes like drug hypersensitivity syndrome. Examine the role of pharmacogenomics in reactions to drugs such as allopurinol and carbamazepine. Learn to differentiate between conditions like erythema multiforme, Stevens-Johnson Syndrome, and hypersensitivity vasculitis. Discover causes and management strategies for drug-induced photosensitivity and allergic interstitial nephritis. Gain insights into prognosis and treatment options, including the use of cyclosporine and acetylcysteine. Enhance your understanding of these complex reactions to improve patient care and outcomes.