Explore the evolution of non-invasive prenatal testing in this 44-minute lecture from the Medical and Population Genetics Primer series at the Broad Institute of MIT and Harvard. Delivered by Guilio Genovese from the Stanley Center for Psychiatric Research, this talk provides an in-depth introduction to the fundamental principles of complex trait genetics related to prenatal testing. Gain insights into human genetic variation, genotyping, DNA sequencing methods, statistics, and data analysis as they pertain to this rapidly advancing field. Designed for a diverse audience including research technicians, graduate students, postdoctoral fellows, and established investigators new to the area, this freely available video offers valuable knowledge on the intersection of medical and population genetics in prenatal care.