Explore molecular modeling of complex biological systems in this 35-minute conference talk from the 2023 Molecular Machine Learning conference at Mila. Dive into an overview of methods and success stories in molecular modeling before delving into chromatin structure and function. Examine histone tail dynamics, the effects of DNA methylation on geometry, and H3 tail modeling. Learn about predicting system responses to perturbations, including modifications and mutations. Gain insights from speaker Anna Panchenko and engage with a Q&A session to deepen your understanding of this cutting-edge field.