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Explore a comprehensive conference talk on messaging and microservices delivered by Clemens Vasters, Lead Architect at Microsoft Azure Service Bus, at GOTO Amsterdam 2016. Delve into the foundational principles of service orientation and their evolution into modern microservices architecture. Learn about the challenges of centralization, the importance of autonomous services, and the benefits they bring to system design. Examine the concepts of layers, tiers, and services in the context of Microsoft Azure. Gain insights into communication patterns, directionality, symmetry, and multiplexing in microservices. Discover the significance of the edge of services, location transparency, and multi-channeling. Understand load leveling, load balancing, and messaging infrastructures. Conclude with a generalized architecture model that synthesizes these concepts for practical application in microservices development.