Explore machine learning-based approaches for designing proteins and small molecules in this 46-minute lecture by Jennifer Listgarten from UC Berkeley. Delve into the motivations behind this research and its applications in directed evolution. Examine various methodologies, including model-based optimization and distribution estimation, while addressing challenges such as black holes and extrapolation. Discover how concepts from image generation and simulations are applied to protein design. Learn about collaborations in the field, domain adaptation techniques, and the importance of uncertainty calibration in deep neural networks. Gain insights into expectation-maximization algorithms and their role in advancing protein engineering and small molecule design.