Save Big on Coursera Plus. 7,000+ courses at $160 off. Limited Time Only! Grab it Explore a groundbreaking statistical reference-free genomics approach that revolutionizes bioinformatics problem-solving in this 43-minute conference talk by Julia Salzman at the Computational Genomics Summer Institute (CGSI) 2023. Delve into the innovative SPLASH algorithm and its implementation, which unifies detection across various genomic applications including cancer research, human disease studies, and non-model organism analysis. Learn how this method surpasses traditional techniques like Pearson's chi-square test, offering a more efficient and scalable solution for discovering novel insights in raw sequencing data. Gain insights into the algorithm's applications in RNA splicing analysis and its potential to reveal previously unrecognized transcriptomic complexity in human single cells. Understand the motivations behind developing such methods and their critical importance in advancing genomic science.