Explore CERN's cloud-native computing infrastructure in this conference talk that delves into the organization's use of Kubernetes and OpenShift. Learn about the benefits and drawbacks of both services, their deployment models, and the integration of various CNCF projects. Discover how CERN manages diverse computing requirements, handles resource allocation, and implements GitOps practices. Gain insights into the challenges and lessons learned from operating large-scale services for thousands of applications and users in a complex computing environment. Understand the role of custom-built projects in integrating cloud-native solutions with traditional infrastructure components such as networking, DNS, storage, and authentication.