Explore the life and groundbreaking work of South African biologist and 2002 Nobel Laureate Sydney Brenner in this 56-minute archival interview from the Society for Neuroscience's "The History of Neuroscience in Autobiography" series. Delve into Brenner's contributions to neuroscience, beginning with his early work in the 1960s and progressing through his pivotal research on wiring diagrams, genetics, and development. Gain insights into the computerization of scientific research, cloning techniques, and the impact of fingerprinting in genetics. Discover Brenner's perspectives on the neuroscience community, behavior studies in C. elegans, and the challenges of simulating complex biological systems. Examine his pragmatic reductionist approach and thoughts on tackling biological complexity, offering a comprehensive overview of a distinguished career that shaped modern neuroscience.