Learn about Graft-Versus-Host Disease (GVHD) in this comprehensive 43-minute lecture by Christine Duncan for OPENPediatrics. Explore the intricacies of hematopoietic stem cell transplantation, including stem cell sources and the pathophysiology of acute and chronic GVHD. Discover risk factors, HLA matching, and the National Institute of Health GVHD criteria. Examine the diagnostic features and manifestations of chronic GVHD in various organs, including skin, mouth, lungs, hair, eyes, genitourinary system, and liver. Understand acute GVHD grading and staging for cutaneous, gastrointestinal, and hepatic involvement. Delve into GVHD prevention, treatment options such as steroids and monoclonal antibodies, and secondary therapies. Gain insights into infectious prophylaxis and prognosis for both acute and chronic GVHD. This lecture provides essential knowledge for healthcare professionals caring for critically ill children undergoing stem cell transplantation.