Explore the future of General Relativity and Quantum Gravity in this 53-minute lecture by T. Padmanabhan at the International Centre for Theoretical Sciences. Delve into the major challenges facing General Relativity, the quantum connection, and the paradigm shift in understanding spacetime as a fluid. Examine concepts such as thermal fluctuations in spacetime, the gravity-thermodynamics connection, and holographic equipartition. Investigate the macroscopic nature of gravity, the concept of zero-point length, and the quantum of information. Discover insights into our strange universe, cosmic information, and potential new perspectives on cosmic evolution. Gain a deeper understanding of the interplay between quantum theory and general relativity, and explore the cutting-edge ideas shaping the next hundred years of research in these fundamental areas of physics.