Explore a comprehensive lecture on formal theory in high energy physics delivered by Juan Maldacena at the 2022 Snowmass Theory Frontier Conference. Delve into fundamental concepts of particle physics, quantum field theory, and the grand goals of high-energy particle research. Examine advanced topics such as strong coupling, confinement, scaling symmetries, and bootstrap ideas. Investigate supersymmetric field theories, dualities, and inflationary primordial fluctuations. Venture beyond quantum field theory to explore quantum gravity, the black hole information problem, and gravitational holography. Gain insights into the importance of diverse approaches in theoretical physics and discover new topologies in this thought-provoking talk that spans the frontiers of modern theoretical physics.