Explore the landscape of Python-based web interface development in this 29-minute EuroPython 2024 conference talk. Delve into packages like Streamlit, Gradio, NiceGUI, reflex, Solara, dominate, ReactPy, and FastUI, examining their potential to revolutionize UI creation. Analyze the viability of building web interfaces solely with Python, considering fundamental trade-offs and appropriate use cases. Investigate whether these tools represent a new era in web development or if engaging with underlying technologies remains essential. Gain insights into the design choices behind various libraries and their potential for future success in the evolving world of web interfaces.