Explore the profound connection between music and the brain in this captivating 1-hour 40-minute dialogue featuring legendary jazz guitarist Pat Metheny and a panel of Society for Neuroscience members. Delve into the universal language of music and its powerful impact on emotions, memory, and healing. Discover the intricacies of improvisation, the importance of listening, and the elusive "X Factor" in musical performance. Examine the mathematical aspects of music, the role of creativity and innovation in both art and science, and the evolution of acoustic and digital sound. Gain insights into the completeness of music as an art form, its potential as a career path, and its ability to encapsulate the entire world within its notes. This thought-provoking discussion offers a unique perspective on the intersection of neuroscience and music, supported by Elsevier.