Explore the challenges and opportunities in responsible AI development through this thought-provoking ACM conference talk. Delve into the pressing need for a human-centered approach in addressing AI risks and failures. Examine the cultural shift required to move the industry from a focus on model performance to holistic AI system development. Discover the tooling advances necessary to empower practitioners in dealing with AI's probabilistic and adaptive capabilities. Draw connections between responsible AI challenges and familiar problems in search and information retrieval. Gain insights into operationalizing human-centered AI, ensuring benefits for people and society, and incorporating human considerations throughout the development process. Learn about the EU AI Act, error prevention principles, and the importance of measurements and metrics in responsible AI practices.