Explore a conference talk from ICAAC 2014 that delves into the benefits of antibiotic stewardship programs in healthcare settings. Learn how these initiatives can significantly reduce antibiotic use without adverse effects while generating substantial cost savings, as demonstrated by a New York hospital's annual savings of over $600,000. Examine case studies of two successful programs, and gain insights from special guests Bill Sheridan of BioCryst and Rich Whitley from the University of Alabama at Birmingham. Discover the impact of antibiotic stewardship on drug resistance, the use of newer antibiotics, and patient outcomes. Investigate the role of computers in improving stewardship efforts, national strategies, and the importance of timely diagnosis. Understand the challenges faced in implementing these programs and the potential for saving lives through improved antibiotic management.