Pharmacological Adaptation of Proteostasis to Ameliorate Aging-associated Degenerative Diseases - 2023
Explore a comprehensive seminar on chemical biology focusing on pharmacological adaptation of proteostasis to address aging-associated degenerative diseases. Delve into the cellular protein homeostasis network and its regulation of proteasome function. Learn about stress-responsive signaling pathways and their role in maintaining cellular homeostasis. Discover how small molecule kinetic stabilizers can potentially stop or slow protein homeostatic deficiencies in amyloid diseases. Examine the clinical efficacy of tafamidis in treating polyneuropathy and cardiomyopathy. Investigate high-throughput screens for drug candidates that enhance lysosomal flux and their potential to extend lifespan and healthspan. Analyze the effects of mTOR inhibitor-independent autophagy activators on clearing toxic protein aggregates in neurodegenerative diseases. Gain insights into the latest research on ameliorating tauopathies and prion-related disorders through proteostasis adaptation.