Modeling the Impact of Stochasticity and Spatial Structure on Homing-Based Gene Drive Spread
Explore a 14-minute conference talk on modeling the impact of stochasticity and spatial structure on homing-based gene drive systems. Delve into the comparison between deterministic reaction-diffusion models and those incorporating stochasticity in gene drive spread. Discover how stochasticity expands the range of fitness costs and initial conditions leading to spatial spread, decreases wave speed in traveling wave solutions, and allows gene drive organisms to potentially overcome selective disadvantage barriers. Examine the similarities and differences between reaction-diffusion models and equivalent metapopulation models on a 5x5 grid. Gain insights into the limitations of deterministic models and the importance of considering stochasticity and spatial structure in gene drive spread modeling as projects move towards field implementation.