Active Forces and Flows that Pattern Organisms by Stephan Grill

Active Forces and Flows that Pattern Organisms by Stephan Grill

Explore the intricate world of biological self-organization in this comprehensive lecture on active forces and flows that pattern organisms. Delve into the complex processes of morphogenesis, from molecular to mesoscale levels, with a focus on the actomyosin cortical layer and its role in cellular dynamics. Examine how active tension gradients drive cortical flows in various organisms, including C. elegans and zebrafish. Investigate the generation of chiral rotating flows and their implications for left-right symmetry breaking in higher vertebrates. Analyze the role of myosin activity in generating active torques and its impact on body axis establishment. Discover mechanochemical pattern formation in active fluids and explore the concept of entrainment in tuning unstable patterns. Gain insights into PAR protein polarization and its relationship to cortical flows. Throughout the lecture, encounter theoretical models and experimental evidence that illuminate the fascinating interplay between active forces, flows, and biological patterning. Read more