GWAS in Structured Populations by Magnus Nordborg
Explore a comprehensive lecture on Genome-Wide Association Studies (GWAS) in structured populations, delivered by Magnus Nordborg at the Third Bangalore School on Population Genetics and Evolution. Delve into the historical context of genetic inheritance, starting with Sir Francis Galton's observations, and progress through the development of GWAS methodology. Examine the challenges and successes of GWAS, including the impact of the Human Genome Project and HapMap Project. Analyze the complexities of population structure confounding and fine mapping in GWAS. Investigate case studies in coronary artery disease, human height, and skin color adaptation. Gain insights into the differences between plant and human genetics, and understand how genome-wide markers contribute to explaining genetic variation.