Dive into the world of cryo-electron microscopy (cryo-EM) with this comprehensive course led by Professor Grant Jensen from the California Institute of Technology. Explore the fundamental principles, techniques, and applications of cryo-EM through a series of lectures covering topics such as electron microscope anatomy, Fourier transforms, image formation, sample preparation, 3D reconstruction, tomography, single particle analysis, and 2D crystallography. Gain hands-on knowledge of the challenges and limitations in biological transmission electron microscopy, and learn about advanced techniques like energy filtering and detector technology. Master the intricacies of data collection, reconstruction workflows, and result interpretation in various cryo-EM applications. Develop a solid foundation in this cutting-edge structural biology technique over 15 hours of in-depth instruction.