Mapping Pre-Cancer to Predict Oesophageal Cancer - Stanford Radiology CEDSS 2022
Explore a comprehensive lecture on mapping pre-cancer to predict future outcomes, focusing on lessons from oesophageal cancer. Delve into the increasing incidence and poor outcomes of oesophageal adenocarcinoma, early detection methods, and the link between mutational processes in ageing and cancer. Examine molecular drivers of Barrett's oesophagus progression, treatments for oesophageal cancer, and curative therapies for dysplasia and early-stage disease. Investigate the gastric origin of Barrett's oesophagus and its malignant transition, as well as risk factors and screening methods for oesophageal adenocarcinoma. Learn about innovative diagnostic tools such as the Cytosponge-TFF3 test, pan-cancer cell-free DNA tests, and breath biopsy. Analyze clinical trial results, surveillance protocols, and biomarkers for dysplasia detection, including p53 immunohistochemistry and DNA copy number alterations. Gain insights into decision-making processes for Barrett's surveillance and potential improvements in risk stratification using advanced biomarkers. Read more