Leveraging Evolutionary Trade-Offs and Phage Selection Pressure to Reduce Bacterial Pathogenicity
Save Big on Coursera Plus. 7,000+ courses at $160 off. Limited Time Only! Grab it Explore the potential of phage therapy in combating bacterial pathogens through a comprehensive lecture on evolutionary trade-offs and selection pressure. Delve into the renewed approach of phage therapy, learning about isolating phage candidates, incorporating genome sequencing, and measuring phage host-range. Understand the characterization of phage binding and how trade-offs can benefit phage therapy. Discover methods to identify phages that drive antibiotic resistance and virulence trade-offs, and determine the likelihood of mutation-caused trade-offs. Examine a case study of emergency phage therapy in human volunteers, analyzing clinical samples before and after treatment. Gain insights into evolutionary predictions and their implications for future therapeutic approaches.